Functional profile of CD4+ and CD8+ T cells in latently infected individuals and patients with active TB

ND Marín, SC París, M Rojas, LF García - Tuberculosis, 2013 - Elsevier
Tuberculosis (TB) is one of the most important infectious diseases around the world. Several
studies have focused on the identification of correlates of protection against TB. Most of them
have concentrated on the study of IFN-γ due to its robust association with protection against
TB. However, given the complexity of the immune response elicited after Mtb infection, other
cytokines should also be considered. In the present study, we evaluated Th1 and Th17
responses and their association with the protection or development of active disease …