HIV–TB co‐infection: mechanisms that drive reactivation of Mycobacterium tuberculosis in HIV infection
Oral diseases, 2016•Wiley Online Library
HIV infection predisposes the host to tuberculosis by impairing the hosts' immune system
principally by killing and altering CD 4 T‐cell function. How HIV infection disrupts CD 4 T‐
cell function, which specifically compromises host immunity to Mycobacterium tuberculosis,
is poorly understood and is a critical roadblock in developing better vaccine‐or immune‐
based strategies to control and monitor TB in HIV‐infected subjects. This review considers
key pathways that are altered in HIV‐infected subjects that impair anti‐TB immunity.
principally by killing and altering CD 4 T‐cell function. How HIV infection disrupts CD 4 T‐
cell function, which specifically compromises host immunity to Mycobacterium tuberculosis,
is poorly understood and is a critical roadblock in developing better vaccine‐or immune‐
based strategies to control and monitor TB in HIV‐infected subjects. This review considers
key pathways that are altered in HIV‐infected subjects that impair anti‐TB immunity.
HIV infection predisposes the host to tuberculosis by impairing the hosts’ immune system principally by killing and altering CD4 T‐cell function. How HIV infection disrupts CD4 T‐cell function, which specifically compromises host immunity to Mycobacterium tuberculosis, is poorly understood and is a critical roadblock in developing better vaccine‐ or immune‐based strategies to control and monitor TB in HIV‐infected subjects. This review considers key pathways that are altered in HIV‐infected subjects that impair anti‐TB immunity.
Wiley Online Library