Adriamycin alters glomerular endothelium to induce proteinuria

M Jeansson, K Bjo, O Tenstad - Journal of the American Society …, 2009 - journals.lww.com
RESULTS Mice with the high dose of adriamycin (AD mice, 25 mg/kg) had a significant
weight-loss from day 3 and onward whereas there was no difference between controls and
low-dose adriamycin mice (ADL mice, 10 mg/kg)(Figure 1). The albumin/creatinine ratio
measured in vivo at day 6 from spot urine was significantly increased from 0.10 (SEM+
0.022,− 0.018) in controls to 0.67 (+ 0.272,− 0.194) in AD mice (P< 0.001). There was no
significant increase for ADL mice, 0.16 (+ 0.030,− 0.025).