Matrix metalloproteinase-7 as a surrogate marker predicts renal Wnt/β-catenin activity in CKD
W He, RJ Tan, Y Li, D Wang, J Nie… - Journal of the American …, 2012 - journals.lww.com
A variety of chronic kidney diseases exhibit reactivation of Wnt/β-catenin signaling. In some
tissues, β-catenin transcriptionally regulates matrix metalloproteinase-7 (MMP-7), but the
association between MMP-7 and Wnt/β-catenin signaling in chronic kidney disease is
unknown. Here, in mouse models of both obstructive nephropathy and focal segmental
glomerulosclerosis (adriamycin nephropathy), we observed upregulation of MMP-7 mRNA
and protein in a time-dependent manner. The pattern and extent of MMP-7 induction were …
tissues, β-catenin transcriptionally regulates matrix metalloproteinase-7 (MMP-7), but the
association between MMP-7 and Wnt/β-catenin signaling in chronic kidney disease is
unknown. Here, in mouse models of both obstructive nephropathy and focal segmental
glomerulosclerosis (adriamycin nephropathy), we observed upregulation of MMP-7 mRNA
and protein in a time-dependent manner. The pattern and extent of MMP-7 induction were …