STAT1 belongs to the STAT family of transcription factors, which comprises seven factors:
STAT1, STAT2, STAT3, STAT4, STAT5A, STAT5B and STAT6. STAT1 is a 91 kDa protein
originally identified as the mediator of the cellular response to interferon (IFN) α, and
thereafter found to be a major component of the cellular response to IFNγ. STAT1 is, in fact,
involved in the response to several cytokines and to growth factors. It is activated by cytokine
receptors via kinases of the JAK family. STAT1 becomes phosphorylated and forms a dimer …