[HTML][HTML] Circulating hematopoietic stem cells do not efficiently home to bone marrow during homeostasis
S McKinney-Freeman, MA Goodell - Experimental hematology, 2004 - Elsevier
OBJECTIVE: Hematopoietic stem cells (HSC), normally resident in bone marrow, can be
detected in the murine and human circulation. It is thought that HSC move in and out of bone
marrow daily and that returning HSC are generally equivalent to their bone marrow
counterparts in phenotype and function. However, large numbers of mononuclear blood
cells are required to rescue animals from lethal irradiation, indicating either that the
prevalence of circulating HSC is low, or they are inherently deficient in their repopulating …
detected in the murine and human circulation. It is thought that HSC move in and out of bone
marrow daily and that returning HSC are generally equivalent to their bone marrow
counterparts in phenotype and function. However, large numbers of mononuclear blood
cells are required to rescue animals from lethal irradiation, indicating either that the
prevalence of circulating HSC is low, or they are inherently deficient in their repopulating …
