Perforin-dependent cytotoxic mechanism in killing by CD8 positive T cells in ginbuna crucian carp, Carassius auratus langsdorfii
H Toda, K Araki, T Moritomo, T Nakanishi - Developmental & Comparative …, 2011 - Elsevier
T cell-mediated cytotoxicity occurs via pathways based on perforin or Fas mechanisms.
Perforin is a protein present in the cytoplasmic granules of CD8+ cytotoxic T lymphocytes
and is secreted to form pores on target cell membranes. In fish, although the involvement of
perforin in cytotoxicity have been suggested for several species, perforin-mediated
cytotoxicity of CD8α+ lymphocyte in conjunction with expression of the perforin gene has not
been reported. In order to investigate the killing mechanism of CD8α+ lymphocytes by …
Perforin is a protein present in the cytoplasmic granules of CD8+ cytotoxic T lymphocytes
and is secreted to form pores on target cell membranes. In fish, although the involvement of
perforin in cytotoxicity have been suggested for several species, perforin-mediated
cytotoxicity of CD8α+ lymphocyte in conjunction with expression of the perforin gene has not
been reported. In order to investigate the killing mechanism of CD8α+ lymphocytes by …
