Effects of latrunculin A on immunological phagocytosis and macrophage spreading-associated changes in the F-actin/G-actin content of the cells
Latrunculin A, a toxin from a Red Sea sponge, was shown to be a very potent inhibitor of
immunological phagocytosis by normal and activated macrophages (obtained from mice
injected ip with LPS), as well as by polymorphonuclear leukocytes. This toxin blocks the
interiorization of the immune complexes but does not interfere with their binding to the
phagocyte (recognition phase); activated macrophages were more susceptible to this
inhibition than normal macrophages and polymorphonuclear leukocytes. The effect of the …
immunological phagocytosis by normal and activated macrophages (obtained from mice
injected ip with LPS), as well as by polymorphonuclear leukocytes. This toxin blocks the
interiorization of the immune complexes but does not interfere with their binding to the
phagocyte (recognition phase); activated macrophages were more susceptible to this
inhibition than normal macrophages and polymorphonuclear leukocytes. The effect of the …