[HTML][HTML] Prostaglandin E2 inhibits α-smooth muscle actin transcription during myofibroblast differentiation via distinct mechanisms of modulation of serum response …

LRK Penke, SK Huang, ES White… - Journal of Biological …, 2014 - ASBMB
Differentiation of lung fibroblasts into contractile protein-expressing myofibroblasts by
transforming growth factor-β1 (TGF-β1) is a critical event in the pathogenesis of pulmonary
fibrosis. Transcription of the contractile protein α-smooth muscle actin (α-SMA) is mediated
by the transcription factor serum-response factor (SRF) along with its co-activator, myocardin-
related transcription factor-A (MRTF-A). The endogenous lipid mediator prostaglandin E 2
(PGE 2) exerts anti-fibrotic effects, including the inhibition of myofibroblast differentiation …