[HTML][HTML] Wnt/β-catenin signaling protects mouse liver against oxidative stress-induced apoptosis through the inhibition of forkhead transcription factor FoxO3
Numerous liver diseases are associated with extensive oxidative tissue damage. It is well
established that Wnt/β-catenin signaling directs multiple hepatocellular processes, including
development, proliferation, regeneration, nutrient homeostasis, and carcinogenesis. It
remains unexplored whether Wnt/β-catenin signaling provides hepatocyte protection against
hepatotoxin-induced apoptosis. Conditional, liver-specific β-catenin knockdown (KD) mice
and their wild-type littermates were challenged by feeding with a hepatotoxin 3, 5 …
established that Wnt/β-catenin signaling directs multiple hepatocellular processes, including
development, proliferation, regeneration, nutrient homeostasis, and carcinogenesis. It
remains unexplored whether Wnt/β-catenin signaling provides hepatocyte protection against
hepatotoxin-induced apoptosis. Conditional, liver-specific β-catenin knockdown (KD) mice
and their wild-type littermates were challenged by feeding with a hepatotoxin 3, 5 …