Background & Aims Hepatoblastoma (HB) is the most common childhood liver cancer and
occasionally presents with histological and clinical features reminiscent of hepatocellular
carcinoma (HCC). Identification of molecular mechanisms that drive the neoplastic
continuation towards more aggressive HCC phenotypes may help to guide the new stage of
targeted therapies. Methods We performed comprehensive studies on genetic and
chromosomal alterations as well as candidate gene function and their clinical relevance …