Antibiotic‐associated disruption of microbiota composition and function in cirrhosis is restored by fecal transplant
JS Bajaj, G Kakiyama, T Savidge, H Takei… - Hepatology, 2018 - journals.lww.com
Abstract Lipocalin‐2 (LCN2), also known as neutrophil gelatinase‐associated lipocalin
(NGAL), a key antibacterial protein, is highly elevated in patients with end‐stage liver
disease that is often associated with bacterial infection. LCN2 is expressed at high levels in
both hepatocytes and neutrophils; however, how hepatocyte‐derived and neutrophil‐
derived LCN2 cooperate to combat bacterial infection remains unclear. Here, by studying
hepatocyte‐specific and myeloid‐specific Lcn2 knockout mice in two models of systemic and …
(NGAL), a key antibacterial protein, is highly elevated in patients with end‐stage liver
disease that is often associated with bacterial infection. LCN2 is expressed at high levels in
both hepatocytes and neutrophils; however, how hepatocyte‐derived and neutrophil‐
derived LCN2 cooperate to combat bacterial infection remains unclear. Here, by studying
hepatocyte‐specific and myeloid‐specific Lcn2 knockout mice in two models of systemic and …