Abstract Chemokine (CC motif) ligand 2 (CCL2), initially identified as monocyte
chemoattractant protein-1 (MCP-1), recruits immune cells to the central nervous system
(CNS) during autoimmune inflammation. CCL2 can be expressed by multiple cell types, but
which cells are responsible for CCL2 function during acute and chronic phases of
autoimmune disease is not known. We determined the role of CCL2 in astrocytes in vivo
during experimental autoimmune encephalomyelitis (EAE) by using Cre-loxP gene deletion …