Aire is not essential for regulating neuroinflammatory disease in mice transgenic for human autoimmune-diseases associated MHC class II genes HLA-DR2b and HLA …
SA Nalawade, N Ji, I Raphael, A Pratt III, E Kraig… - Cellular …, 2018 - Elsevier
The human autoimmune disease-associated HLA alleles HLA-DR2b (DRB1* 1501) and
HLA-DR4 (DRB1* 0401) are strongly linked to increased susceptibility for multiple sclerosis
(MS) and rheumatoid arthritis (RA), respectively. The underlying mechanisms are not fully
understood, but these MHC alleles may shape the repertoire of pathogenic T cells via
central tolerance. The transcription factor autoimmune regulator (AIRE) promotes central T
cell tolerance via ectopic expression of tissue-specific antigens (TSAs). Aire deficiency in …
HLA-DR4 (DRB1* 0401) are strongly linked to increased susceptibility for multiple sclerosis
(MS) and rheumatoid arthritis (RA), respectively. The underlying mechanisms are not fully
understood, but these MHC alleles may shape the repertoire of pathogenic T cells via
central tolerance. The transcription factor autoimmune regulator (AIRE) promotes central T
cell tolerance via ectopic expression of tissue-specific antigens (TSAs). Aire deficiency in …
