Gene-promoter hypermethylation as a biomarker in lung cancer
SA Belinsky - Nature Reviews Cancer, 2004 - nature.com
SA Belinsky
Nature Reviews Cancer, 2004•nature.comSilencing of genes by aberrant promoter hypermethylation is now recognized as a crucial
component in cancer initiation and progression. Highly sensitive assays have been
developed to assess gene-promoter methylation in biological fluids. The detection of
methylated genes in sputum could lead to the development of a screening test to non-
invasively identify early cancer in high-risk people.
component in cancer initiation and progression. Highly sensitive assays have been
developed to assess gene-promoter methylation in biological fluids. The detection of
methylated genes in sputum could lead to the development of a screening test to non-
invasively identify early cancer in high-risk people.
Abstract
Silencing of genes by aberrant promoter hypermethylation is now recognized as a crucial component in cancer initiation and progression. Highly sensitive assays have been developed to assess gene-promoter methylation in biological fluids. The detection of methylated genes in sputum could lead to the development of a screening test to non-invasively identify early cancer in high-risk people.
nature.com
