[HTML][HTML] Neuron-derived neurotrophic factor functions as a novel modulator that enhances endothelial cell function and revascularization processes
K Ohashi, T Enomoto, Y Joki, R Shibata… - Journal of Biological …, 2014 - ASBMB
Strategies to stimulate revascularization are valuable for cardiovascular diseases. Here we
identify neuron-derived neurotrophic factor (NDNF)/epidermacan as a secreted molecule
that is up-regulated in endothelial cells in ischemic limbs of mice. NDNF was secreted from
cultured human endothelial cells, and its secretion was stimulated by hypoxia. NDNF
promoted endothelial cell network formation and survival in vitro through activation of
Akt/endothelial NOS (eNOS) signaling involving integrin αvβ3. Conversely, siRNA-mediated …
identify neuron-derived neurotrophic factor (NDNF)/epidermacan as a secreted molecule
that is up-regulated in endothelial cells in ischemic limbs of mice. NDNF was secreted from
cultured human endothelial cells, and its secretion was stimulated by hypoxia. NDNF
promoted endothelial cell network formation and survival in vitro through activation of
Akt/endothelial NOS (eNOS) signaling involving integrin αvβ3. Conversely, siRNA-mediated …