The perinexus is a recently identified microdomain surrounding the cardiac gap junction that
contains elevated levels of connexin43 and the sodium channel protein, Na v 1.5. Ongoing
work has established a role for the perinexus in regulating gap junction aggregation.
However, recent studies have raised the possibility of a perinexal contribution at the gap
junction cleft to intercellular propagation of action potential via non-electrotonic
mechanisms. The latter possibility could modify the current theoretical understanding of …