γδ T cells in cancer
B Silva-Santos, K Serre, H Norell - Nature reviews immunology, 2015 - nature.com
B Silva-Santos, K Serre, H Norell
Nature reviews immunology, 2015•nature.comWith the promise of T cell-based therapy for cancer finally becoming reality, this Review
focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells
have well-established protective roles in cancer, largely on the basis of their potent
cytotoxicity and interferon-γ production. Besides this, recent studies have revealed a series
of tumour-promoting functions that are linked to interleukin-17-producing γδ T cells. Here,
we integrate the current knowledge from both human and mouse studies to highlight the …
focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells
have well-established protective roles in cancer, largely on the basis of their potent
cytotoxicity and interferon-γ production. Besides this, recent studies have revealed a series
of tumour-promoting functions that are linked to interleukin-17-producing γδ T cells. Here,
we integrate the current knowledge from both human and mouse studies to highlight the …
Abstract
With the promise of T cell-based therapy for cancer finally becoming reality, this Review focuses on the less-studied γδ T cell lineage and its diverse responses to tumours. γδ T cells have well-established protective roles in cancer, largely on the basis of their potent cytotoxicity and interferon-γ production. Besides this, recent studies have revealed a series of tumour-promoting functions that are linked to interleukin-17-producing γδ T cells. Here, we integrate the current knowledge from both human and mouse studies to highlight the potential of γδ T cell modulation to improve cancer immunotherapy.
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