Activation of hypoxia-inducible factor-1α in type 2 alveolar epithelial cell is a major driver of acute inflammation following lung contusion
MV Suresh, SK Ramakrishnan, B Thomas… - Critical care …, 2014 - journals.lww.com
Objective: Lung contusion is a major risk factor for the development of acute respiratory
distress syndrome. Hypoxia-inducible factor-1α is the primary transcription factor that is
responsible for regulating the cellular response to changes in oxygen tension. We set to
determine if hypoxia-inducible factor-1α plays a role in the pathogenesis of acute
inflammatory response and injury in lung contusion. Design: Nonlethal closed-chest
unilateral lung contusion was induced in a hypoxia reporter mouse model and type 2 cell …
distress syndrome. Hypoxia-inducible factor-1α is the primary transcription factor that is
responsible for regulating the cellular response to changes in oxygen tension. We set to
determine if hypoxia-inducible factor-1α plays a role in the pathogenesis of acute
inflammatory response and injury in lung contusion. Design: Nonlethal closed-chest
unilateral lung contusion was induced in a hypoxia reporter mouse model and type 2 cell …