Interactions between HIV-1 and the cell-autonomous innate immune system
GJ Towers, M Noursadeghi - Cell host & microbe, 2014 - cell.com
Cell host & microbe, 2014•cell.com
HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of
intensive research, we are still unraveling the molecular details of the host-pathogen
interactions that enable this virus to escape immune clearance and cause
immunodeficiency. Here we explore a series of recent studies that consider how HIV-1
interacts with the cell-autonomous innate immune system as it navigates its way in and out
of host cells. We discuss how these studies improve our knowledge of HIV-1 and host …
intensive research, we are still unraveling the molecular details of the host-pathogen
interactions that enable this virus to escape immune clearance and cause
immunodeficiency. Here we explore a series of recent studies that consider how HIV-1
interacts with the cell-autonomous innate immune system as it navigates its way in and out
of host cells. We discuss how these studies improve our knowledge of HIV-1 and host …
HIV-1 was recognized as the cause of AIDS in humans in 1984. Despite 30 years of intensive research, we are still unraveling the molecular details of the host-pathogen interactions that enable this virus to escape immune clearance and cause immunodeficiency. Here we explore a series of recent studies that consider how HIV-1 interacts with the cell-autonomous innate immune system as it navigates its way in and out of host cells. We discuss how these studies improve our knowledge of HIV-1 and host biology as well as increase our understanding of transmission, persistence, and immunodeficiency and the potential for therapeutic or prophylactic interventions.
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