[HTML][HTML] Identification of neutrophil exocytosis inhibitors (Nexinhibs), small molecule inhibitors of neutrophil exocytosis and inflammation: druggability of the small …
JL Johnson, M Ramadass, J He, SJ Brown… - Journal of Biological …, 2016 - ASBMB
Neutrophils constitute the first line of cellular defense in response to bacterial and fungal
infections and rely on granular proteins to kill microorganisms, but uncontrolled secretion of
neutrophil cargos is injurious to the host and should be closely regulated. Thus, increased
plasma levels of neutrophil secretory proteins, including myeloperoxidase and elastase, are
associated with tissue damage and are hallmarks of systemic inflammation. Here, we
describe a novel high-throughput screening approach to identify small molecule inhibitors of …
infections and rely on granular proteins to kill microorganisms, but uncontrolled secretion of
neutrophil cargos is injurious to the host and should be closely regulated. Thus, increased
plasma levels of neutrophil secretory proteins, including myeloperoxidase and elastase, are
associated with tissue damage and are hallmarks of systemic inflammation. Here, we
describe a novel high-throughput screening approach to identify small molecule inhibitors of …