Pressure myography to study the function and structure of isolated small arteries
OL Schjørring, R Carlsson, U Simonsen - Methods in mouse …, 2015 - Springer
OL Schjørring, R Carlsson, U Simonsen
Methods in mouse atherosclerosis, 2015•SpringerSmall arteries play an important role in regulation of peripheral resistance and organ
perfusion. Here we describe a series of methods allowing measurements in pressurized
segments of small arteries from the systemic and coronary circulation of mice as well as
other species. The pressure myography techniques described include measurements of wall
structure, wall stress, strain, and myogenic tone. The pressurized perfused small arteries
also allow evaluation of responses to increases in pressure, flow, and drugs, where the main …
perfusion. Here we describe a series of methods allowing measurements in pressurized
segments of small arteries from the systemic and coronary circulation of mice as well as
other species. The pressure myography techniques described include measurements of wall
structure, wall stress, strain, and myogenic tone. The pressurized perfused small arteries
also allow evaluation of responses to increases in pressure, flow, and drugs, where the main …
Abstract
Small arteries play an important role in regulation of peripheral resistance and organ perfusion. Here we describe a series of methods allowing measurements in pressurized segments of small arteries from the systemic and coronary circulation of mice as well as other species. The pressure myography techniques described include measurements of wall structure, wall stress, strain, and myogenic tone. The pressurized perfused small arteries also allow evaluation of responses to increases in pressure, flow, and drugs, where the main readout is changes in vascular diameter.
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