Endoplasmic reticulum (ER) calcium signaling is implicated in a myriad of coordinated
cellular processes. The ER calcium content is tightly regulated as it allows a favorable
environment for protein folding, in addition to operate as a major reservoir for fast and
specific release of calcium. Altered ER homeostasis impacts protein folding, activating the
unfolded protein response (UPR) as a rescue mechanism to restore proteostasis. ER
calcium release impacts mitochondrial metabolism and also fine-tunes the threshold to …