[HTML][HTML] Small molecule–based inhibition of MEK1/2 proteins dampens inflammatory responses to malaria, reduces parasite load, and mitigates pathogenic outcomes

X Wu, KK Dayanand, RP Thylur, CC Norbury… - Journal of Biological …, 2017 - ASBMB
Malaria infections cause several systemic and severe single-or multi-organ pathologies,
killing hundreds of thousands of people annually. Considering the existing widespread
resistance of malaria parasites to anti-parasitic drugs and their high propensity to develop
drug resistance, alternative strategies are required to manage malaria infections. Because
malaria is a host immune response–driven disease, one approach is based on gaining a
detailed understanding of the molecular and cellular processes that modulate malaria …