Insulin expression in cultured astrocytes and the decrease by amyloid β
K Takano, K Koarashi, K Kawabe, M Itakura… - Neurochemistry …, 2018 - Elsevier
Insulin resistance in brain has been reported in Alzheimer's diseases (AD). Insulin signaling
is important for homeostasis in brain function and reported to be disturbed in neurons
leading to tau phosphorylation and neurofibrillary tangles. Many investigations of insulin in
neurons have been reported; however, it has not been reported whether astrocytes also
produce insulin. In the present study, we assessed the expression of insulin in astrocytes
cultured from rat embryonic brain and the effects of amyloid β 1-42 (Aβ) and …
is important for homeostasis in brain function and reported to be disturbed in neurons
leading to tau phosphorylation and neurofibrillary tangles. Many investigations of insulin in
neurons have been reported; however, it has not been reported whether astrocytes also
produce insulin. In the present study, we assessed the expression of insulin in astrocytes
cultured from rat embryonic brain and the effects of amyloid β 1-42 (Aβ) and …
