Identification of longevity mutants is crucial for genetic approach to dissect the molecular
mechanism of aging and longevity determination. In Drosophila melanogaster, several
mutations have been shown to extend the longevity: methuselah encoding a putative G-
protein coupled receptor, Indy encoding a sodium dicarboxylate cotransporter, chico
encoding insulin receptor substrate, and InR encoding the insulin-like receptor. Extended
longevity phenotypes were also observed in transgenic flies overexpressing antioxidant …