Cardiovascular effects of renal distal tubule deletion of the FGF receptor 1 gene
The bone-derived hormone fibroblast growth factor–23 (FGF-23) activates complexes
composed of FGF receptors (FGFRs), including FGFR1, and α-Klotho in the kidney distal
tubule (DT), leading to increased sodium retention and hypertension. However, the role of
FGFR1 in regulating renal processes linked to hypertension is unclear. Here, we
investigated the effects of selective FGFR1 loss in the DT. Conditional knockout (cKO) of
FGFR1 in the DT (FGFR1 DT-cKO mice) resulted in left ventricular hypertrophy (LVH) and …
composed of FGF receptors (FGFRs), including FGFR1, and α-Klotho in the kidney distal
tubule (DT), leading to increased sodium retention and hypertension. However, the role of
FGFR1 in regulating renal processes linked to hypertension is unclear. Here, we
investigated the effects of selective FGFR1 loss in the DT. Conditional knockout (cKO) of
FGFR1 in the DT (FGFR1 DT-cKO mice) resulted in left ventricular hypertrophy (LVH) and …