[HTML][HTML] The cooperation of FGF receptor and Klotho is involved in excretory canal development and regulation of metabolic homeostasis in Caenorhabditis elegans
UM Polanska, E Edwards, DG Fernig… - Journal of Biological …, 2011 - ASBMB
FGFs have traditionally been associated with cell proliferation, morphogenesis, and
development; yet, a subfamily of FGFs (FGF19,-21, and-23) functions as hormones to
regulate glucose, lipid, phosphate, and vitamin D metabolism with impact on energy balance
and aging. In mammals, Klotho and beta-Klotho are type 1 transmembrane proteins that
function as obligatory co-factors for endocrine FGFs to bind to their cognate FGF receptors
(FGFRs). Mutations in Klotho/beta-Klotho or fgf19,-21, or-23 are associated with a number of …
development; yet, a subfamily of FGFs (FGF19,-21, and-23) functions as hormones to
regulate glucose, lipid, phosphate, and vitamin D metabolism with impact on energy balance
and aging. In mammals, Klotho and beta-Klotho are type 1 transmembrane proteins that
function as obligatory co-factors for endocrine FGFs to bind to their cognate FGF receptors
(FGFRs). Mutations in Klotho/beta-Klotho or fgf19,-21, or-23 are associated with a number of …