Excess BMI in childhood: a modifiable risk factor for type 1 diabetes development?
CT Ferrara, SM Geyer, YF Liu, C Evans-Molina… - Diabetes …, 2017 - Am Diabetes Assoc
CT Ferrara, SM Geyer, YF Liu, C Evans-Molina, IM Libman, R Besser, DJ Becker…
Diabetes care, 2017•Am Diabetes AssocOBJECTIVE We aimed to determine the effect of elevated BMI over time on the progression
to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS We studied 1,117
children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of
patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age-and sex-
adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive
partitioning and multivariate analyses yielded sex-and age-specific ceBMI thresholds for …
to type 1 diabetes in youth. RESEARCH DESIGN AND METHODS We studied 1,117
children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of
patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age-and sex-
adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive
partitioning and multivariate analyses yielded sex-and age-specific ceBMI thresholds for …
OBJECTIVE
We aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth.
RESEARCH DESIGN AND METHODS
We studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk.
RESULTS
Higher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects and in females versus males.
CONCLUSIONS
Elevated BMI is associated with increased risk of diabetes progression in pediatric autoantibody-positive relatives, but the effect varies by sex and age.
Am Diabetes Assoc