Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
AG Ziegler, M Rewers, O Simell, T Simell, J Lempainen… - Jama, 2013 - jamanetwork.com
Importance Type 1 diabetes usually has a preclinical phase identified by circulating islet
autoantibodies, but the rate of progression to diabetes after seroconversion to islet
autoantibodies is uncertain. Objective To determine the rate of progression to diabetes after
islet autoantibody seroconversion. Design, Setting, and Participants Data were pooled from
prospective cohort studies performed in Colorado (recruitment, 1993-2006), Finland
(recruitment, 1994-2009), and Germany (recruitment, 1989-2006) examining children …
autoantibodies, but the rate of progression to diabetes after seroconversion to islet
autoantibodies is uncertain. Objective To determine the rate of progression to diabetes after
islet autoantibody seroconversion. Design, Setting, and Participants Data were pooled from
prospective cohort studies performed in Colorado (recruitment, 1993-2006), Finland
(recruitment, 1994-2009), and Germany (recruitment, 1989-2006) examining children …