[HTML][HTML] Transcription factor SOX9 plays a key role in the regulation of visual cycle gene expression in the retinal pigment epithelium

T Masuda, K Wahlin, J Wan, J Hu, J Maruotti… - Journal of Biological …, 2014 - ASBMB
The retinal pigment epithelium (RPE) performs specialized functions to support retinal
photoreceptors, including regeneration of the visual chromophore. Enzymes and carrier
proteins in the visual cycle function sequentially to regenerate and continuously supply 11-
cis-retinal to retinal photoreceptor cells. However, it is unknown how the expression of the
visual cycle genes is coordinated at the transcriptional level. Here, we show that the
proximal upstream regions of six visual cycle genes contain chromatin-accessible sex …