HIF proteins connect the RB-E2F factors to angiogenesis
WJ Bakker, BGMW Weijts, B Westendorp… - Transcription, 2013 - Taylor & Francis
WJ Bakker, BGMW Weijts, B Westendorp, A de Bruin
Transcription, 2013•Taylor & FrancisRecently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis
through transcriptional control of VEGFA in cooperation with HIF. Here we investigate the
existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the
RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.
through transcriptional control of VEGFA in cooperation with HIF. Here we investigate the
existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the
RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.
Recently, we showed that E2F7 and E2F8 (E2F7/8) are critical regulators of angiogenesis through transcriptional control of VEGFA in cooperation with HIF. Here we investigate the existence of other novel putative angiogenic E2F7/8-HIF targets, and discuss the role of the RB-E2F pathway in regulating angiogenesis during embryonic and tumor development.
Taylor & Francis Online