Cellular calcium transient alternans are beat-to-beat alternations in the peak cytosolic
calcium concentration exhibited by cardiac cells during rapid electrical stimulation or under
pathological conditions. Calcium transient alternans promote action potential duration
alternans, which have been linked to the onset of life-threatening ventricular arrhythmias.
Here we use a recently developed physiologically detailed mathematical model of
ventricular myocytes to investigate both stochastic and deterministic aspects of intracellular …