Development of the cardiac conduction system in zebrafish
KL Poon, M Liebling, I Kondrychyn, T Brand… - Gene Expression …, 2016 - Elsevier
The cardiac conduction system (CCS) propagates and coordinates the electrical excitation
that originates from the pacemaker cells, throughout the heart, resulting in rhythmic
heartbeat. Its defects result in life-threatening arrhythmias and sudden cardiac death.
Understanding of the factors involved in the formation and function of the CCS remains
incomplete. By transposon assisted transgenesis, we have developed enhancer trap (ET)
lines of zebrafish that express fluorescent protein in the pacemaker cells at the sino-atrial …
that originates from the pacemaker cells, throughout the heart, resulting in rhythmic
heartbeat. Its defects result in life-threatening arrhythmias and sudden cardiac death.
Understanding of the factors involved in the formation and function of the CCS remains
incomplete. By transposon assisted transgenesis, we have developed enhancer trap (ET)
lines of zebrafish that express fluorescent protein in the pacemaker cells at the sino-atrial …