[HTML][HTML] The flipside of the power of engineered T cells: observed and potential toxicities of genetically modified T cells as therapy
F Bedoya, MJ Frigault, MV Maus - Molecular Therapy, 2017 - cell.com
F Bedoya, MJ Frigault, MV Maus
Molecular Therapy, 2017•cell.comAutologous T cells modified to recognize novel antigen targets are a novel form of therapy
for cancer. We review the various potential forms of observed and hypothetical toxicities
associated with genetically modified T cells. Despite the focus on toxicities in this review, re-
directed T cells represent a powerful and highly effective form of anti-cancer therapy; we
remain optimistic that the common toxicities will become routinely manageable and that
some theoretical toxicity will be exceedingly rare, if ever observed.
for cancer. We review the various potential forms of observed and hypothetical toxicities
associated with genetically modified T cells. Despite the focus on toxicities in this review, re-
directed T cells represent a powerful and highly effective form of anti-cancer therapy; we
remain optimistic that the common toxicities will become routinely manageable and that
some theoretical toxicity will be exceedingly rare, if ever observed.
Autologous T cells modified to recognize novel antigen targets are a novel form of therapy for cancer. We review the various potential forms of observed and hypothetical toxicities associated with genetically modified T cells. Despite the focus on toxicities in this review, re-directed T cells represent a powerful and highly effective form of anti-cancer therapy; we remain optimistic that the common toxicities will become routinely manageable and that some theoretical toxicity will be exceedingly rare, if ever observed.
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