[HTML][HTML] MRI with gadofosveset: A potential marker for permeability in myocardial infarction
B Lavin, A Protti, S Lorrio, X Dong, A Phinikaridou… - Atherosclerosis, 2018 - Elsevier
Background and aims Acute ischemia is associated with myocardial endothelial damage
and microvessel formation, resulting in leakage of plasma albumin into the myocardial
extravascular space. In this study, we tested whether an albumin-binding intravascular
contrast agent (gadofosveset) allows for improved quantification of myocardial permeability
compared to the conventional extracellular contrast agent Gd-DTPA using late gadolinium
enhancement (LGE) and T1 mapping in vivo. Methods MI was induced in C57BL/6 mice (n …
and microvessel formation, resulting in leakage of plasma albumin into the myocardial
extravascular space. In this study, we tested whether an albumin-binding intravascular
contrast agent (gadofosveset) allows for improved quantification of myocardial permeability
compared to the conventional extracellular contrast agent Gd-DTPA using late gadolinium
enhancement (LGE) and T1 mapping in vivo. Methods MI was induced in C57BL/6 mice (n …
