Prelamin A accumulation in endothelial cells induces premature senescence and functional impairment
N Bonello-Palot, S Simoncini, S Robert, P Bourgeois… - Atherosclerosis, 2014 - Elsevier
Background Defects in lamin A maturation result in premature aging syndromes and severe
atherosclerosis as observed in the Hutchinson–Gilford Progeria Syndrome. In age-related
atherosclerosis, several features of cellular senescence have been characterized in
endothelial cells including telomere shortening and increased oxidative stress. However, to
date, very little is known about lamin A alterations in these cells. Objectives To study lamin A-
related senescence and its consequences in the activation status of primary endothelial …
atherosclerosis as observed in the Hutchinson–Gilford Progeria Syndrome. In age-related
atherosclerosis, several features of cellular senescence have been characterized in
endothelial cells including telomere shortening and increased oxidative stress. However, to
date, very little is known about lamin A alterations in these cells. Objectives To study lamin A-
related senescence and its consequences in the activation status of primary endothelial …