[HTML][HTML] Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance
WC Zhang, LJ Du, XJ Zheng, XQ Chen, C Shi… - Journal of Biological …, 2018 - ASBMB
Type I IFN production and signaling in macrophages play critical roles in innate immune
responses. High salt (ie high concentrations of NaCl) has been proposed to be an important
environmental factor that influences immune responses in multiple ways. However, it
remains unknown whether high salt regulates type I IFN production and signaling in
macrophages. Here, we demonstrated that high salt promoted IFNβ production and its
signaling in both human and mouse macrophages, and consequentially primed …
responses. High salt (ie high concentrations of NaCl) has been proposed to be an important
environmental factor that influences immune responses in multiple ways. However, it
remains unknown whether high salt regulates type I IFN production and signaling in
macrophages. Here, we demonstrated that high salt promoted IFNβ production and its
signaling in both human and mouse macrophages, and consequentially primed …