Inhibition on angiotensin-converting enzyme exerts beneficial effects on trabecular bone in orchidectomized mice
XF Chen, XL Li, JX Liu, J Xu, YY Zhao, M Yang… - Pharmacological …, 2018 - Elsevier
Background This study aimed to study the osteo-preservative effects of captopril, an inhibitor
on angiotensin-converting enzyme (ACE), on bone mass, micro-architecture and
histomorphology as well as the modulation of captopril on skeletal renin-angiotensin system
(RAS) and regulators for bone metabolism in mice with bilateral orchidectomy. Methods The
orchidectomized (ORX) mice were orally administered with vehicle or captopril at low dose
(10 mg/kg) and high dose (50 mg/kg) for six weeks. The distal femoral end, the proximal …
on angiotensin-converting enzyme (ACE), on bone mass, micro-architecture and
histomorphology as well as the modulation of captopril on skeletal renin-angiotensin system
(RAS) and regulators for bone metabolism in mice with bilateral orchidectomy. Methods The
orchidectomized (ORX) mice were orally administered with vehicle or captopril at low dose
(10 mg/kg) and high dose (50 mg/kg) for six weeks. The distal femoral end, the proximal …