Molecular control of bone remodeling and osteoporosis

YY Kong, JM Penninger - Experimental Gerontology, 2000 - Elsevier
Osteoprotegerin ligand (OPGL, TNFS11) and its receptor RANK (TNFRS11A) are essential
for the development and activation of osteoclasts and critical regulators of physiological
bone remodeling and osteoporosis. Production of OPGL by activated T cells can directly
regulate osteoclastogenesis and bone remodeling. This may explain why autoimmune
diseases, cancers, leukemias, asthma and chronic viral infections such as hepatitis and HIV
result in systemic and local bone loss. OPGL is also the pathogenetic factor that causes …