Our recent animal and human studies revealed that chronic hyponatremia is a previously
unrecognized cause of osteoporosis that is associated with increased osteoclast numbers in
a rat model of the human disease of the syndrome of inappropriate antidiuretic hormone
secretion (SIADH). We used cellular and molecular approaches to demonstrate that
sustained low extracellular sodium ion concentrations ([Na+]) directly stimulate
osteoclastogenesis and resorptive activity and to explore the mechanisms underlying this …