[HTML][HTML] TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells
BR Wong, J Rho, J Arron, E Robinson, J Orlinick… - Journal of Biological …, 1997 - ASBMB
A novel member of the tumor necrosis factor (TNF) cytokine family, designated TRANCE,
was cloned during a search for apoptosis-regulatory genes using a somatic cell genetic
approach in T cell hybridomas. The TRANCEgene encodes a type II membrane protein of
316 amino acids with a predicted molecular mass of 35 kDa. Its extracellular domain is most
closely related to TRAIL, FasL, and TNF. TRANCE is an immediate early gene up-regulated
by TCR stimulation and is controlled by calcineurin-regulated transcription factors. TRANCE …
was cloned during a search for apoptosis-regulatory genes using a somatic cell genetic
approach in T cell hybridomas. The TRANCEgene encodes a type II membrane protein of
316 amino acids with a predicted molecular mass of 35 kDa. Its extracellular domain is most
closely related to TRAIL, FasL, and TNF. TRANCE is an immediate early gene up-regulated
by TCR stimulation and is controlled by calcineurin-regulated transcription factors. TRANCE …