Resveratrol inhibits mTOR signaling by promoting the interaction between mTOR and DEPTOR
Resveratrol (RSV) is a naturally occurring polyphenol that has been found to exert
antioxidant, anti-inflammatory, and neuroprotective properties. However, how RSV exerts its
beneficial health effects remains largely unknown. Here, we show that RSV inhibits insulin-
and leucine-stimulated mTOR signaling in C2C12 fibroblasts via a Sirt1-independent
mechanism. Treating C2C12 cells with RSV dramatically inhibited insulin-stimulated Akt, S6
kinase, and 4E-BP1 phosphorylation but had little effect on tyrosine phosphorylation of the …
antioxidant, anti-inflammatory, and neuroprotective properties. However, how RSV exerts its
beneficial health effects remains largely unknown. Here, we show that RSV inhibits insulin-
and leucine-stimulated mTOR signaling in C2C12 fibroblasts via a Sirt1-independent
mechanism. Treating C2C12 cells with RSV dramatically inhibited insulin-stimulated Akt, S6
kinase, and 4E-BP1 phosphorylation but had little effect on tyrosine phosphorylation of the …
