Peanut oral immunotherapy results in increased antigen-induced regulatory T-cell function and hypomethylation of forkhead box protein 3 (FOXP3)
A Syed, MA Garcia, SC Lyu, R Bucayu, A Kohli… - Journal of allergy and …, 2014 - Elsevier
Background The mechanisms contributing to clinical immune tolerance remain incompletely
understood. This study provides evidence for specific immune mechanisms that are
associated with a model of operationally defined clinical tolerance. Objective Our overall
objective was to study laboratory changes associated with clinical immune tolerance in
antigen-induced T cells, basophils, and antibodies in subjects undergoing oral
immunotherapy (OIT) for peanut allergy. Methods In a phase 1 single-site study, we studied …
understood. This study provides evidence for specific immune mechanisms that are
associated with a model of operationally defined clinical tolerance. Objective Our overall
objective was to study laboratory changes associated with clinical immune tolerance in
antigen-induced T cells, basophils, and antibodies in subjects undergoing oral
immunotherapy (OIT) for peanut allergy. Methods In a phase 1 single-site study, we studied …