[HTML][HTML] Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity
Y Chen, LN Yang, L Cheng, S Tu, SJ Guo… - Molecular & Cellular …, 2013 - ASBMB
Bcl2-associated athanogene 3 (BAG3), a member of the BAG family of co-chaperones, plays
a critical role in regulating apoptosis, development, cell motility, autophagy, and tumor
metastasis and in mediating cell adaptive responses to stressful stimuli. BAG3 carries a BAG
domain, a WW domain, and a proline-rich repeat (PXXP), all of which mediate binding to
different partners. To elucidate BAG3's interaction network at the molecular level, we
employed quantitative immunoprecipitation combined with knockdown and human …
a critical role in regulating apoptosis, development, cell motility, autophagy, and tumor
metastasis and in mediating cell adaptive responses to stressful stimuli. BAG3 carries a BAG
domain, a WW domain, and a proline-rich repeat (PXXP), all of which mediate binding to
different partners. To elucidate BAG3's interaction network at the molecular level, we
employed quantitative immunoprecipitation combined with knockdown and human …