Diabetic nephropathy is the most common cause of CKD and represents a large and
ominous public health problem. Patients with diabetic kidney disease have exceptionally
high rates of cardiovascular morbidity and mortality. In fact, the excess mortality among
patients with diabetes appears to be largely limited to the subgroup with kidney disease and
explained by their high burden of cardiovascular disease. The mechanisms underlying the
strong association between diabetic kidney disease and various forms of cardiovascular …