[HTML][HTML] Cytomegalovirus replication within the lung allograft is associated with bronchiolitis obliterans syndrome
M Paraskeva, M Bailey, BJ Levvey, AP Griffiths… - American Journal of …, 2011 - Elsevier
Early studies reported cytomegalovirus (CMV) pneumonitis as a risk factor for development
of bronchiolitis obliterans syndrome (BOS) following lung transplantation. While
improvements in antiviral prophylaxis have resulted in a decreased incidence of CMV
pneumonitis, molecular diagnostic techniques allow diagnosis of subclinical CMV
replication in the allograft. We hypothesized that this subclinical CMV replication was
associated with development of BOS. We retrospectively evaluated 192 lung transplant …
of bronchiolitis obliterans syndrome (BOS) following lung transplantation. While
improvements in antiviral prophylaxis have resulted in a decreased incidence of CMV
pneumonitis, molecular diagnostic techniques allow diagnosis of subclinical CMV
replication in the allograft. We hypothesized that this subclinical CMV replication was
associated with development of BOS. We retrospectively evaluated 192 lung transplant …
