[HTML][HTML] An inhibitor of the proteasomal deubiquitinating enzyme USP14 induces tau elimination in cultured neurons
M Boselli, BH Lee, J Robert, MA Prado, SW Min… - Journal of Biological …, 2017 - ASBMB
The ubiquitin-proteasome system (UPS) is responsible for most selective protein
degradation in eukaryotes and regulates numerous cellular processes, including cell cycle
control and protein quality control. A component of this system, the deubiquitinating enzyme
USP14, associates with the proteasome where it can rescue substrates from degradation by
removal of the ubiquitin tag. We previously found that a small-molecule inhibitor of USP14,
known as IU1, can increase the rate of degradation of a subset of proteasome substrates …
degradation in eukaryotes and regulates numerous cellular processes, including cell cycle
control and protein quality control. A component of this system, the deubiquitinating enzyme
USP14, associates with the proteasome where it can rescue substrates from degradation by
removal of the ubiquitin tag. We previously found that a small-molecule inhibitor of USP14,
known as IU1, can increase the rate of degradation of a subset of proteasome substrates …