Mast cells are critical players in allergic reactions, but they have also been shown to be
important in immunity and recently also in inflammatory diseases, especially asthma.
Migraines are episodic, typically unilateral, throbbing headaches that occur more frequently
in patients with allergy and asthma implying involvement of meningeal and/or brain mast
cells. These mast cells are located perivascularly, in close association with neurons
especially in the dura, where they can be activated following trigeminal nerve, as well as …