Methods. The experimental protocol for both patients and healthy subjects was designed as
a randomized, double-blind, vehicle controlled, right-left study and was approved by the
local ethics committee. All participants gave their written informed consent. Aprepitant was
blended at a 5% concentration in a lipophilic vehicle in accordance with the European
Union Good Manufacturing Practice rules. A visual analog scale (VAS) was used to score
pruritus. Thirteen patients (8 women and 5 men; age range, 33-82 years; median age, 57 …